|
T1532 |
Pidotimod
|
|
Others
,
Antibacterial
|
|
Pidotimod is a synthetic dipeptide with immunomodulatory properties. |
|
T6054 |
GSK256066
|
|
PDE
|
|
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2. |
|
T30258 |
AZD-4818
|
CCR1 antagonist |
CCR
|
|
AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease. |
|
T4503 |
Talniflumate
|
Somalgen |
Chloride channel
,
COX
,
N-Acetylglucosaminyltransferase
,
Anion Exchanger
|
|
Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition o... |
|
T6445 |
Cilomilast
|
SB-207499,Ariflo |
PDE
|
|
Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3. |
|
T6547 |
Ipratropium Bromide
|
Sch 1000,Itrop,Atrovent |
AChR
|
|
Ipratropium Bromide (Sch 1000) is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema. |
|
T26795 |
PXS-4728A
|
BI-1467335,BI 1467335,BI1467335,BI-1467335 HCl |
Monoamine Oxidase
|
|
BI-1467335 HCl(BI 1467335) is a selective, orally active inhibitor of semicarbazide-sensitive amine oxidase (SSAO) that helps improve chronic obstructive pulmonary disease in mice[2]. |
|
T0098 |
Ipratropium bromide monohydrate
|
Ipratropium bromide hydrate |
AChR
|
|
Ipratropium bromide monohydrate (Ipratropium bromide hydrate) is a muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial... |
|
T1083L |
Theophylline monohydrate
|
Quibron |
HDAC
,
PDE
,
Adenosine Receptor
|
|
Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a ... |
|
T33386 |
Milveterol HCl
|
Milveterol,GSK-159797,GSK 159797,GSK159797 |
Adrenergic Receptor
|
|
Milveterol HCl is a long-acting β(2) -adrenergic receptor agonist for the potential treatment of chronic obstructive pulmonary disease (COPD). |
|
T26760 |
Bedoradrine sulfate
|
KUR1246,MN 221 sulfate,KUR1246 sulfate,MN221 sulfate,KUR 1246 sulfate,MN-221 sulfate,KUR 1246,KUR-1246 sulfate,MN-221,MN 221,MN221,KUR-1246 |
Adrenergic Receptor
|
|
Bedoradrine sulfate (MN-221 sulfate) is a super-selective beta2 agonist for the treatment of asthma exacerbations and chronic obstructive pulmonary disease. |
|
T9877 |
Tiquizium
|
|
AChR
|
|
Tiquizium has effective Antimuscarinic effect, and causes significant bronchodilation in patients with chronic obstructive pulmonary disease. |
|
T12850 |
Dilmapimod
|
SB-681323,GW 681323 |
p38 MAPK
,
Autophagy
|
|
Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease. |
|
T30232 |
AWD 12-281
|
GSK 842470,GSK-842470,AWD12-281,AWD-12-281,GW 842470 |
PDE
|
|
AWD 12-281 is a selective phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory and bronchodilator activity used in the study of chronic obstructive pulmonary disease (COPD). |
|
T6505 |
Formoterol fumarate
|
Formoterol Hemifumarate,NSC 299587,Eformoterol Hemifumarate,CGP 25827A,Eformoterol,YM 08316 |
Adrenergic Receptor
|
|
Formoterol fumarate (Eformoterol Hemifumarate), an effective, specific and long-acting β2-adrenoceptor agonist, is utilized in the treatment of chronic obstructive pulmonary disease(COPD) and asthma. |
|
T31207 |
GSK233705
|
Darotropium bromide,GSK 233705,GSK-233705B,GSK233705,GSK233705B,GSK-233705,GSK 233705B |
AChR
|
|
GSK233705 (Darotropium bromide) is a muscarinic receptor antagonist used in conjunction with the prevention and treatment of chronic obstructive pulmonary disease (COPD) and asthma in humans. |
|
T35530 |
IHMT-PI3Kδ-372
|
IHMT-PI3Kδ-372 |
PI3K
|
|
IHMT-PI3Kδ-372 is a selective inhibitor of PI3Kδ with an IC50 of 14 nM and can be used in studies about chronic obstructive pulmonary disease. |
|
T28991 |
Tofimilast
|
CP-325,366,CP-325366,CP325366,CP 325,366,CP 325366 |
PDE
|
|
Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease. |
|
T15431 |
Nemiralisib
|
GSK2269557 (free base),GSK2269557 |
PI3K
|
|
Nemiralisib（GSK-2269557 free base） is an orally available, potent and specific PI3Kδ inhibitor with a pKi of 9.9.Nemiralisib is used for the treatment of respiratory diseases including chronic obstructive pulmonary disea... |
|
T70047 |
Bedoradrine
|
Bedoradrine free base |
Adrenergic Receptor
|
|
Bedoradrine free base is a novel, highly selective β2-adrenoceptor agonist for the treatment of asthma and chronic obstructive pulmonary disease (COPD). |
|
T33941 |
PF-03635659
|
PF03635659,PF 03635659 |
AChR
|
|
PF-03635659 is a potent and long dissociative half-life muscarinic M3 antagonist (Ki: 0.2 nM) that shows potential for the treatment of chronic obstructive pulmonary disease (COPD). |
|
T21389 |
Enprofylline
|
Enprofilina,3-propylxanthine,3-n-Propylxanthine,Enprofyllinum |
Others
|
|
Enprofylline (Enprofilina), a bronchodilator, acts primarily as a competitive nonselective phosphodiesterase inhibitor. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of sick... |
|
T7717 |
Sodium 2-oxopropanoate
|
Sodium pyruvate |
Reactive Oxygen Species
,
Endogenous Metabolite
|
|
Sodium 2-oxopropanoate (Sodium pyruvate) is a antioxidant potentially used to treatment of chronic obstructive pulmonary disease. |
|
T72031 |
BI 1015550
|
|
PDE
|
|
BI 1015550 is an orally active inhibitor of PDE4B with an IC 50 value of 7.2 nM. BI 1015550 has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmo... |
|
T6653 |
Salmeterol Xinafoate
|
Salmetedur,GR 33343X xinafoate,Arial |
HIV Protease
,
Adrenergic Receptor
|
|
Salmeterol Xinafoate (GR 33343X xinafoate) is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptom... |
|
T76910 |
Astegolimab
|
RG 6149,MSTT 1041A |
Interleukin
|
|
Astegolimab (RG 6149) is a humanised IgG2 monoclonal antibody that targets the IL-33 receptor and inhibits IL-33 signalling. Astegolimab is used in the study of chronic obstructive pulmonary disease (COPD) and severe ast... |
|
T72918 |
JNJ-49095397
|
RV568 |
Antiviral
,
p38 MAPK
|
|
JNJ-49095397 (RV568) is a selective p38 MAPK-α and p38 MAPK--γ kinase inhibitor with anti-inflammatory activity and potential antiviral activity for chronic obstructive pulmonary disease (COPD), cystic fibrosis, and resp... |
|
T1179 |
Tiotropium bromide
|
Tiopropium,BA679 BR |
AChR
|
|
Tiotropium bromide (BA679 BR) is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a muscarinic receptor antagonist, on topical a... |
|
T10201 |
PDE IV-IN-1
|
|
PDE
|
|
PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary disease and other inflammatory diseases, and is a potential compound... |
|
T60196 |
IHMT-PI3Kδ-372 S-isomer
|
|
PI3K
|
|
IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 S-isomer shows high selectivity over other class I PI3Ks (56∼83 fold) and other protein kinases. IHMT-PI3Kδ-372 can ... |
|
T10497 |
Benralizumab
|
BIW-8405,MEDI-563 |
Apoptosis
,
IL Receptor
,
Interleukin
|
|
|
|
T27290 |
Etamiphylline Camsylate
|
R 3588,Etamiphylline Camsilate,Milliphylline,Soluphyline,R-3588,R3588 |
|
|
Etamiphylline Camsylate is used for the treatment of chronic obstructive pulmonary disease (COPD). |
|
T1139L |
Levosalbutamol Hydrochloride
|
R-albuterol,R albuterol,Xopenex,(R)-albuterol |
|
|
Levosalbutamol Hydrochloride is a β2-adrenergic receptor agonist. It is used to treat asthma and chronic obstructive pulmonary disease. |
|
T28519 |
Reproterol hydrochloride
|
D 1959,D1959,D-1959,W-2946M,W 2946M |
|
|
Reproterol hydrochloride, a β2 adrenoreceptor agonist, is used to treat asthma and chronic obstructive pulmonary disease (COPD). |
|
T33425 |
MK-0969
|
J-104135,J104135,J 104135,MK 0969,MK0969 |
|
|
MK-0969 (J-104135) is a possible M3 antagonist for the treatment of chronic obstructive pulmonary disease. |
|
T20829 |
Pivampicillin
|
|
|
|
Pivampicillin, a pivalate ester analog of Ampicillin, is used to treat chronic obstructive pulmonary disease (COPD) in children and young adults. |
|
T30265 |
Navafenterol saccharinate
|
AZD8871 saccharinate,LAS-191351 saccharinate,LAS191351 saccharinate,AZD-8871 saccharinate |
|
|
AZD-8871 saccharinate is a dual-acting bronchodilator which may be useful in the treatment of Chronic Obstructive Pulmonary Disease (COPD). |
|
T68240 |
AZD-9819
|
|
|
|
AZD-9819 is an inhibitor of human neutrophil elastase for potential treatment of chronic obstructive pulmonary disease (COPD). |
|
T38944 |
Tetomilast
|
OPC-6535,Tetomilast |
|
|
Tetomilast (OPC-6535) is a phosphodiesterase-4 (PDE4) inhibitor, potentially effective in treating inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD). |
|
T30264 |
Navafenterol
|
AZD8871,LAS-191351,AZD 8871,LAS191351,AZD-8871,LAS 191351 |
|
|
AZD-8871 can present a novel treatment approach to chronic obstructive pulmonary disease [COPD] and potentially also asthma (in combination with an inhaled corticosteroid [ICS]). |
|
T23936 |
D-4418
|
|
|
|
D-4418 is a PDE4 inhibitor. It has been in development as a novel anti-inflammatory therapy with asthma and chronic obstructive pulmonary disease being primary indications. |
|
T70116 |
Tretoquinol l-form hydrochloride
|
|
|
|
Tretoquinol l-form hydrochloride is a β2-adrenergic receptor agonist used to treat asthma and chronic obstructive pulmonary disease. |
|
T28774 |
Sibenadet hydrochloride
|
Sibenadet HCl,Viozan,FPL-68397,AR-C-68397AA,ARC-68397AA |
|
|
Sibenadet, a D2/beta2-agonist, is potential useful for the treatment of symptoms of chronic obstructive pulmonary disease. |
|
T26737 |
Bamifylline Hydrochloride
|
BAX-2793Z,AC 3810,AC-3810,BAX2793Z,BAX 2793Z |
|
|
Bamifylline Hydrochloride, an adenosine A1 receptor antagonist, is uesd to treat bronchiectasis and chronic obstructive pulmonary disease. |
|
T29518 |
Abediterol
|
LAS100977,LAS 100977,LAS-100977 |
|
|
Abediterol (LAS100977) is a new potent, long-acting inhaled beta (2) -adrenergic receptor agonist being developed for the treatment of asthma and chronic obstructive pulmonary disease. |
|
TP2406 |
Seretide
|
Adoair,Advair,Fluticasone/Salmeterol |
|
|
Seretide, a combination of fluticasone and salmeterol, controls symptoms of asthma and chronic obstructive pulmonary disease (COPD). |
|
T70925 |
GS-5759
|
|
|
|
GS-5759 is a bifunctional ß2-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action. |
|
T13277 |
Valategrast
|
R-411 free base |
Others
|
|
Valategrast is a potent and orally active dual antagonist of integrin α4β1 (VLA-4) and α4β7, with the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment. |
|
T16417 |
Oxitropium Bromide
|
|
AChR
|
|
|
|
T11483 |
GSK256066 Trifluoroacetate
|
GSK 256066 Trifluoroacetate,GSK256066 (2,2,2-trifluoroacetic acid) |
PDE
|
|
GSK 256066 Trifluoroacetate is a selective and high-affinity phosphodiesterase 4 (PDE) inhibitor (IC50: 3.2 pM for PDE4B). It can be used for the treatment of chronic obstructive pulmonary disease. |
